Neuronal Changes in the Diabetic Cornea: Perspectives for Neuroprotection

نویسندگان

  • Guzel Bikbova
  • Toshiyuki Oshitari
  • Takayuki Baba
  • Shuichi Yamamoto
چکیده

Diabetic neuropathy is associated with neurotrophic ulcerations of the skin and cornea. Decreased corneal sensitivity and impaired innervation lead to weakened epithelial wound healing predisposing patients to ocular complications such as corneal infections, stromal opacification, and surface irregularity. This review presents recent findings on impaired corneal innervation in diabetic individuals, and the findings suggest that corneal neuropathy might be an early indicator of diabetic neuropathy. Additionally, the recent findings for neuroprotective and regenerative therapy for diabetic keratopathy are presented.

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عنوان ژورنال:

دوره 2016  شماره 

صفحات  -

تاریخ انتشار 2016